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hif1α signaling pathway  (MedChemExpress)
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MedChemExpress hif1α signaling pathway
Hif1α Signaling Pathway, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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hif1α  (Santa Cruz Biotechnology)
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hif 1α  (ABclonal Biotechnology)
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iPSC-EVs modulate hypoxia-adaptive and angiogenic signaling pathways in HUVECs by downregulating negative regulators of the EGFR <t>and</t> <t>HIF-1α</t> signaling axes. HUVECs were cultured under hypoxia and starvation stress conditions and treated with iPSC-EVs or DPBS. (A) RT-qPCR analysis of miRNA target genes. EV treatment resulted in the significant downregulation of ERRFI1 and VHL mRNA levels compared to the DPBS control. (n = 4). (B) Consistent with the suppression of ERRFI1 , EV treatment significantly increased p-EGFR (Tyr1068) levels and the p-EGFR/EGFR ratio while total EGFR protein levels remained unchanged. Additionally, HIF-1α protein significantly accumulated in the EV group, consistent with the downregulation of VHL . (C) Analysis of downstream effectors. The activation of upstream sensors propagated to downstream cascades, evidenced by significantly elevated phosphorylation of ERK1/2 and increased expression of the pro-angiogenic factor VEGF compared to the control. (D) Evaluation of cell proliferation. The EV-treated group exhibited significantly upregulated PCNA protein levels, confirming that the activated signaling pathways resulted in enhanced endothelial proliferation. Data are presented as mean ± SD. n = 4 (A), n = 5 (B, EGFR), and n = 6 (B, HIF-1α, C and D). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
Hif 1α, supplied by ABclonal Biotechnology, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hif1%CE%B1/HIF1%CE%B1+Rabbit+pAb/pmc13544078-131-4-7
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hif1a  (ABclonal Biotechnology)
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iPSC-EVs modulate hypoxia-adaptive and angiogenic signaling pathways in HUVECs by downregulating negative regulators of the EGFR <t>and</t> <t>HIF-1α</t> signaling axes. HUVECs were cultured under hypoxia and starvation stress conditions and treated with iPSC-EVs or DPBS. (A) RT-qPCR analysis of miRNA target genes. EV treatment resulted in the significant downregulation of ERRFI1 and VHL mRNA levels compared to the DPBS control. (n = 4). (B) Consistent with the suppression of ERRFI1 , EV treatment significantly increased p-EGFR (Tyr1068) levels and the p-EGFR/EGFR ratio while total EGFR protein levels remained unchanged. Additionally, HIF-1α protein significantly accumulated in the EV group, consistent with the downregulation of VHL . (C) Analysis of downstream effectors. The activation of upstream sensors propagated to downstream cascades, evidenced by significantly elevated phosphorylation of ERK1/2 and increased expression of the pro-angiogenic factor VEGF compared to the control. (D) Evaluation of cell proliferation. The EV-treated group exhibited significantly upregulated PCNA protein levels, confirming that the activated signaling pathways resulted in enhanced endothelial proliferation. Data are presented as mean ± SD. n = 4 (A), n = 5 (B, EGFR), and n = 6 (B, HIF-1α, C and D). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
Hif1a, supplied by ABclonal Biotechnology, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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anti hypoxia inducible factor 1α hif1α  (Boster Bio)
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iPSC-EVs modulate hypoxia-adaptive and angiogenic signaling pathways in HUVECs by downregulating negative regulators of the EGFR <t>and</t> <t>HIF-1α</t> signaling axes. HUVECs were cultured under hypoxia and starvation stress conditions and treated with iPSC-EVs or DPBS. (A) RT-qPCR analysis of miRNA target genes. EV treatment resulted in the significant downregulation of ERRFI1 and VHL mRNA levels compared to the DPBS control. (n = 4). (B) Consistent with the suppression of ERRFI1 , EV treatment significantly increased p-EGFR (Tyr1068) levels and the p-EGFR/EGFR ratio while total EGFR protein levels remained unchanged. Additionally, HIF-1α protein significantly accumulated in the EV group, consistent with the downregulation of VHL . (C) Analysis of downstream effectors. The activation of upstream sensors propagated to downstream cascades, evidenced by significantly elevated phosphorylation of ERK1/2 and increased expression of the pro-angiogenic factor VEGF compared to the control. (D) Evaluation of cell proliferation. The EV-treated group exhibited significantly upregulated PCNA protein levels, confirming that the activated signaling pathways resulted in enhanced endothelial proliferation. Data are presented as mean ± SD. n = 4 (A), n = 5 (B, EGFR), and n = 6 (B, HIF-1α, C and D). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
Anti Hypoxia Inducible Factor 1α Hif1α, supplied by Boster Bio, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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china hif 1α  (ABclonal Biotechnology)
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iPSC-EVs modulate hypoxia-adaptive and angiogenic signaling pathways in HUVECs by downregulating negative regulators of the EGFR <t>and</t> <t>HIF-1α</t> signaling axes. HUVECs were cultured under hypoxia and starvation stress conditions and treated with iPSC-EVs or DPBS. (A) RT-qPCR analysis of miRNA target genes. EV treatment resulted in the significant downregulation of ERRFI1 and VHL mRNA levels compared to the DPBS control. (n = 4). (B) Consistent with the suppression of ERRFI1 , EV treatment significantly increased p-EGFR (Tyr1068) levels and the p-EGFR/EGFR ratio while total EGFR protein levels remained unchanged. Additionally, HIF-1α protein significantly accumulated in the EV group, consistent with the downregulation of VHL . (C) Analysis of downstream effectors. The activation of upstream sensors propagated to downstream cascades, evidenced by significantly elevated phosphorylation of ERK1/2 and increased expression of the pro-angiogenic factor VEGF compared to the control. (D) Evaluation of cell proliferation. The EV-treated group exhibited significantly upregulated PCNA protein levels, confirming that the activated signaling pathways resulted in enhanced endothelial proliferation. Data are presented as mean ± SD. n = 4 (A), n = 5 (B, EGFR), and n = 6 (B, HIF-1α, C and D). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
China Hif 1α, supplied by ABclonal Biotechnology, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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anti hif1α  (ABclonal Biotechnology)
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iPSC-EVs modulate hypoxia-adaptive and angiogenic signaling pathways in HUVECs by downregulating negative regulators of the EGFR <t>and</t> <t>HIF-1α</t> signaling axes. HUVECs were cultured under hypoxia and starvation stress conditions and treated with iPSC-EVs or DPBS. (A) RT-qPCR analysis of miRNA target genes. EV treatment resulted in the significant downregulation of ERRFI1 and VHL mRNA levels compared to the DPBS control. (n = 4). (B) Consistent with the suppression of ERRFI1 , EV treatment significantly increased p-EGFR (Tyr1068) levels and the p-EGFR/EGFR ratio while total EGFR protein levels remained unchanged. Additionally, HIF-1α protein significantly accumulated in the EV group, consistent with the downregulation of VHL . (C) Analysis of downstream effectors. The activation of upstream sensors propagated to downstream cascades, evidenced by significantly elevated phosphorylation of ERK1/2 and increased expression of the pro-angiogenic factor VEGF compared to the control. (D) Evaluation of cell proliferation. The EV-treated group exhibited significantly upregulated PCNA protein levels, confirming that the activated signaling pathways resulted in enhanced endothelial proliferation. Data are presented as mean ± SD. n = 4 (A), n = 5 (B, EGFR), and n = 6 (B, HIF-1α, C and D). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
Anti Hif1α, supplied by ABclonal Biotechnology, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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hypoxia inducible factor 1 subunit alpha rabbit polyclonal antibody  (ABclonal Biotechnology)
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ABclonal Biotechnology hypoxia inducible factor 1 subunit alpha rabbit polyclonal antibody
iPSC-EVs modulate hypoxia-adaptive and angiogenic signaling pathways in HUVECs by downregulating negative regulators of the EGFR <t>and</t> <t>HIF-1α</t> signaling axes. HUVECs were cultured under hypoxia and starvation stress conditions and treated with iPSC-EVs or DPBS. (A) RT-qPCR analysis of miRNA target genes. EV treatment resulted in the significant downregulation of ERRFI1 and VHL mRNA levels compared to the DPBS control. (n = 4). (B) Consistent with the suppression of ERRFI1 , EV treatment significantly increased p-EGFR (Tyr1068) levels and the p-EGFR/EGFR ratio while total EGFR protein levels remained unchanged. Additionally, HIF-1α protein significantly accumulated in the EV group, consistent with the downregulation of VHL . (C) Analysis of downstream effectors. The activation of upstream sensors propagated to downstream cascades, evidenced by significantly elevated phosphorylation of ERK1/2 and increased expression of the pro-angiogenic factor VEGF compared to the control. (D) Evaluation of cell proliferation. The EV-treated group exhibited significantly upregulated PCNA protein levels, confirming that the activated signaling pathways resulted in enhanced endothelial proliferation. Data are presented as mean ± SD. n = 4 (A), n = 5 (B, EGFR), and n = 6 (B, HIF-1α, C and D). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
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iPSC-EVs modulate hypoxia-adaptive and angiogenic signaling pathways in HUVECs by downregulating negative regulators of the EGFR and HIF-1α signaling axes. HUVECs were cultured under hypoxia and starvation stress conditions and treated with iPSC-EVs or DPBS. (A) RT-qPCR analysis of miRNA target genes. EV treatment resulted in the significant downregulation of ERRFI1 and VHL mRNA levels compared to the DPBS control. (n = 4). (B) Consistent with the suppression of ERRFI1 , EV treatment significantly increased p-EGFR (Tyr1068) levels and the p-EGFR/EGFR ratio while total EGFR protein levels remained unchanged. Additionally, HIF-1α protein significantly accumulated in the EV group, consistent with the downregulation of VHL . (C) Analysis of downstream effectors. The activation of upstream sensors propagated to downstream cascades, evidenced by significantly elevated phosphorylation of ERK1/2 and increased expression of the pro-angiogenic factor VEGF compared to the control. (D) Evaluation of cell proliferation. The EV-treated group exhibited significantly upregulated PCNA protein levels, confirming that the activated signaling pathways resulted in enhanced endothelial proliferation. Data are presented as mean ± SD. n = 4 (A), n = 5 (B, EGFR), and n = 6 (B, HIF-1α, C and D). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

Journal: Materials Today Bio

Article Title: Human iPSC-EV-loaded nanofiber stent coatings accelerate vascular repair by enhancing EGFR/HIF-1α signaling and suppressing ROCK1-mediated remodeling

doi: 10.1016/j.mtbio.2026.103564

Figure Lengend Snippet: iPSC-EVs modulate hypoxia-adaptive and angiogenic signaling pathways in HUVECs by downregulating negative regulators of the EGFR and HIF-1α signaling axes. HUVECs were cultured under hypoxia and starvation stress conditions and treated with iPSC-EVs or DPBS. (A) RT-qPCR analysis of miRNA target genes. EV treatment resulted in the significant downregulation of ERRFI1 and VHL mRNA levels compared to the DPBS control. (n = 4). (B) Consistent with the suppression of ERRFI1 , EV treatment significantly increased p-EGFR (Tyr1068) levels and the p-EGFR/EGFR ratio while total EGFR protein levels remained unchanged. Additionally, HIF-1α protein significantly accumulated in the EV group, consistent with the downregulation of VHL . (C) Analysis of downstream effectors. The activation of upstream sensors propagated to downstream cascades, evidenced by significantly elevated phosphorylation of ERK1/2 and increased expression of the pro-angiogenic factor VEGF compared to the control. (D) Evaluation of cell proliferation. The EV-treated group exhibited significantly upregulated PCNA protein levels, confirming that the activated signaling pathways resulted in enhanced endothelial proliferation. Data are presented as mean ± SD. n = 4 (A), n = 5 (B, EGFR), and n = 6 (B, HIF-1α, C and D). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

Article Snippet: Angiogenesis and endothelial markers: HIF-1α (1:1000, A11945, ABclonal), VEGF (1:1000, A23759, ABclonal), and CD31 (1:1000, A18014, ABclonal).

Techniques: Protein-Protein interactions, Cell Culture, Quantitative RT-PCR, Control, Activation Assay, Phospho-proteomics, Expressing